Absolutely! I use an EQ in the in the loop to fine tune things and a EB volume pedal in front to back off on distortion/volume. If it wasn't for those little parts of songs that need wah, tremlo, etc...I would be straight in all the time. I don't care how transparent pedals are..something just isn't the same. If you can't get the sou d from your amp, you have the wrong amp. There is no "decent" sound. There us THE sound you need to have. I don't change my sound too much for different songs. Why would I? Oh, I do throw an attenuator in there too.