Remove pick attack around 1kHz with EQ will do it but your tone alters with it. You will always expect some pick sounds with high gain distortion. One way to deal with it is to have your amp control loudness, not your guitar volume knob. Set that to about 5 or 6 out of 10 and turn your amp volume up instead of the gain for increases in volume. Pick attack sounds are not always unwanted. However, sometimes they can of course sound quite bad.