I like the fat 50s pick ups, but my favorite single coil is a Lindy Fralin hot blues. My EJ Strat has a Dimarzio HS2 in the bridge with the top coil wired only and it cuts a lot of the noise while still sounding like an old Fender single coil. EJ had a '54 Strat that had a Dimarzio HS2 wired this way.