I always used to crank my guitar volume + tone to 10 and set my amps and eq pedals to get the tones I wanted. Then I was jamming at a buddies place and his neighbour, an old seasoned session musician, told me I had it all wrong. Initially my pride took a hit and I told him all 10’s is the best sound you can get out of a guitar so you need to start with the best source. He cracked a huge smile. He told me this was because I was setting my amp wrong too. He asked me to set my Lester volume and tone each to 6 or 7 then re adjust my amp for some middle of the road crunch: My amp was now set way brighter than normal.. in my mind this was a shit setting but overall it sounded fantastic. He then asked me to dial down the volume and turn up the tone. I was getting a nice clean tone. He then told me to crank the volume and dial the tone down to taste and in between these settings were 90% of what I play.. without even touching my amp or a pedal! I’ve since refined my tones this way and can’t stand any of my old amp/ guitar settings. Then he handed me his strat and said turn up your amp gain a bit and find me all those sounds without touching anything else on the amp: I was in the ballpark quickly... For 30 years before this plugging in a strat meant rearranging the shit out of my amp settings. If you’re open minded try the old guys advice, worked for me. Thought I’d share this since sadly he’s no longer around to share it himself.
Yes, especially for the bridge pickup on a Strat. I always move the tone control wire from the middle to the bridge pickup, I like an 0.047uf best with vintage spec single coil's.